Supplemental Material ====================== Benchmark Files ++++++++++++++++ All samples contain TMT labeled E.Coli cells on human background. The different Instruments (Orbitrap, Lumos, HF, HF-X) were run in DDA mode. Machines: HF : P0109699E18 P0109699E19 P0109699E22 HF-X : P0174319B7 P0174319B8 P0174319B9 Lumos: P0109699K8 P0109699K9 P0109699K10 OrbiElite: P81464G09 P81464G10 Raw Files are accesible via PRIDE: All benchmark files (igz) used in the paper can be found here: https://drive.google.com/drive/folders/1GbN0cAqiyAEljcuooYKkqW4rcKlOlc5n